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| PROSITE documentation PDOC00049 |
Ribosomal protein L23 signature
Description:
Ribosomal protein L23 is one of the proteins from the large ribosomal subunit.
In Escherichia coli, L23 is known to bind a specific region on the 23S rRNA;
in yeast, the corresponding protein binds to a homologous site on the 26S rRNA
[1]. It belongs to a family of ribosomal proteins which, on the basis of
sequence similarities [2,3,4], groups:
- Eubacterial L23.
- Algal and plant chloroplast L23.
- Archaebacterial L23.
- Mammalian L23A.
- Caenorhabditis elegans L23A (F55D10.2).
- Fungi L25.
- Yeast mitochondrial YmL41 (gene MRPL41 or MRP20).
As a signature pattern, we selected a small conserved region in the C-terminal
section of these proteins, which is probably involved in rRNA-binding [2].
Last update:
July 1999 / Pattern and text revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| RIBOSOMAL_L23, PS00050; Ribosomal protein L23 signature (PATTERN) |
| Consensus pattern: |
[RK](2)-[AM]-[IVFYT]-[IV]-[RKT]-L-[STANEQK]-x(7)-[LIVMFT]
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| Sequences known to belong to this class detected by the pattern: |
ALL, except for yeast mitochondrial YmL41 |
| Other sequence(s) detected in Swiss-Prot: |
1 |
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| Matching PDB structures:
1FFK 1GIY 1GS2 1JJ2 ... [ALL] |
References:
| 1 |
Authors | El Baradi T.T.A.L., Raue H.A., van de Regt C.H.F., Verbree E.C., Planta R.J. |
| Source | EMBO J. 4:210-2107(1985). |
| 2 |
Authors | Raue H.A., Otaka E., Suzuki K. |
| Title | Structural comparison of 26S rRNA-binding ribosomal protein L25 from two different yeast strains and the equivalent proteins from three eubacteria and two chloroplasts. |
| Source | J. Mol. Evol. 28:418-426(1989). |
| PubMed ID | 2501503 |
| 3 |
Authors | Fearon K., Mason T.L. |
| Title | Structure and function of MRP20 and MRP49, the nuclear genes for two proteins of the 54 S subunit of the yeast mitochondrial ribosome. |
| Source | J. Biol. Chem. 267:5162-5170(1992). |
| PubMed ID | 1544898 |
| 4 |
Authors | Otaka E., Hashimoto T., Mizuta K. |
| Source | Protein Seq. Data Anal. 5:285-300(1993). |
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