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PROSITE documentation PDOC00053

Ribosomal protein S11 signature

Description:

Ribosomal protein S11 [1] plays an essential role in selecting the correct tRNA in protein biosynthesis. It is located on the large lobe of the small ribosomal subunit. S11 belongs to a family of ribosomal proteins which, on the basis of sequence similarities, groups [2]:

  • Eubacterial S11.
  • Algal and plant chloroplast S11.
  • Cyanelle S11.
  • Archaebacterial S11.
  • Marchantia polymorpha and Prototheca wickerhamii mitochondrial S11.
  • Acanthamoeba castellanii mitochondrial S11.
  • Neurospora crassa S14 (crp-2).
  • Yeast S14 (RP59 or CRY1).
  • Mammalian, Drosophila, Trypanosoma, and plant S14.
  • Caenorhabditis elegans S14 (F37C12.9).

We selected one of the best conserved regions in these proteins as a signature pattern.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S11, PS00054; Ribosomal protein S11 signature  (PATTERN)
Consensus pattern: [LIVMFR]-x-[GSTACQI]-[LIVMF]-x(1,2)-[GSTALVM]-x(0,1)-[GSN]-[LIVMFY]-x-[LIVM]-x(4)-[DEN]-x-[TS]-[PS]-x-[PA]-[STCHF]-[DN]
Sequences known to belong to this class detected by the pattern: ALL, except for some mitochondrial S11
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00054
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00054
• Scan Swiss-Prot/TrEMBL entries against PS00054
• view ligand binding statistics
Matching PDB structures: 1FJG 1GIX 1HNW 1HNX ... [ALL]

References:

1 AuthorsKimura T., Nishikawa M., Fujisawa J.
TitleUncleaved env gp160 of human immunodeficiency virus type 1 is degraded within the Golgi apparatus but not lysosomes in COS-1 cells.
SourceFEBS Lett. 390:15-20(1996).
PubMed ID8706820
2 AuthorsOtaka E., Hashimoto T., Mizuta K.
SourceProtein Seq. Data Anal. 5:285-300(1993).

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