{PDOC00053} {PS00054; RIBOSOMAL_S11} {BEGIN} *********************************** * Ribosomal protein S11 signature * *********************************** Ribosomal protein S11 [1] plays an essential role in selecting the correct tRNA in protein biosynthesis. It is located on the large lobe of the small ribosomal subunit. S11 belongs to a family of ribosomal proteins which, on the basis of sequence similarities, groups [2]: - Eubacterial S11. - Algal and plant chloroplast S11. - Cyanelle S11. - Archaebacterial S11. - Marchantia polymorpha and Prototheca wickerhamii mitochondrial S11. - Acanthamoeba castellanii mitochondrial S11. - Neurospora crassa S14 (crp-2). - Yeast S14 (RP59 or CRY1). - Mammalian, Drosophila, Trypanosoma, and plant S14. - Caenorhabditis elegans S14 (F37C12.9). We selected one of the best conserved regions in these proteins as a signature pattern. -Consensus pattern: [LIVMFR]-x-[GSTACQI]-[LIVMF]-x(1,2)-[GSTALVM]-x(0,1)- [GSN]-[LIVMFY]-x-[LIVM]-x(4)-[DEN]-x-[TS]-[PS]-x-[PA]- [STCHF]-[DN] -Sequences known to belong to this class detected by the pattern: ALL, except for some mitochondrial S11. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. [ 1] Kimura T., Nishikawa M., Fujisawa J. "Uncleaved env gp160 of human immunodeficiency virus type 1 is degraded within the Golgi apparatus but not lysosomes in COS-1 cells." FEBS Lett. 390:15-20(1996). PubMed=8706820 [ 2] Otaka E., Hashimoto T., Mizuta K. Protein Seq. Data Anal. 5:285-300(1993). -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}