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PROSITE documentation PDOC00067

Glucose-6-phosphate dehydrogenase active site

Description:

Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) (G6PD) [1] catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and can be used as a signature pattern.

Last update:

April 2006 / Pattern revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

G6P_DEHYDROGENASE, PS00069; Glucose-6-phosphate dehydrogenase active site  (PATTERN)
Consensus pattern: D-H-[YF]-L-G-K-[EQK]
K is the active site residue
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
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Matching PDB structures: 1DPG 1E77 1H93 1H94 ... [ALL]

Reference:

1 AuthorsJeffery J., Persson B., Wood I., Bergman T., Jeffery R., Joernvall H.
TitleGlucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure.
SourceEur. J. Biochem. 212:41-49(1993).
PubMed ID8444164

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