|PROSITE documentation PDOC00067|
Glucose-6-phosphate dehydrogenase (EC 220.127.116.11) (G6PD)  catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and can be used as a signature pattern.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Jeffery J., Persson B., Wood I., Bergman T., Jeffery R., Joernvall H.|
|Title||Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure.|
|Source||Eur. J. Biochem. 212:41-49(1993).|