Acyl-CoA dehydrogenases [1,2,3] are enzymes that catalyze the α,β-dehydrogenation of acyl-CoA esters and transfer electrons to ETF, the electron
transfer protein. Acyl-CoA dehydrogenases are FAD flavoproteins. This family
Five eukaryotic isozymes that catalyze the first step of the β-oxidation
cycles for fatty acids with various chain lengths. These are short (SCAD)
(EC 126.96.36.199), medium (MCAD) (EC 188.8.131.52), long (LCAD) (EC 184.108.40.206),
very-long (VLCAD) and short/branched (SBCAD) chain acyl-CoA dehydrogenases.
These enzymes are located in the mitochondrion. They are all homotetrameric
proteins of about 400 amino acid residues except VLCAD which is a dimer
and which contains, in its mature form, about 600 residues.
Glutaryl-CoA dehydrogenase (EC 220.127.116.11) (GCDH), which is involved in the
catabolism of lysine, hydroxylysine and tryptophan.
Isovaleryl-CoA dehydrogenase (EC 18.104.22.168) (IVD), involved in the
catabolism of leucine.
Acyl-coA dehydrogenases acdA and mmgC from Bacillus subtilis.
Butyryl-CoA dehydrogenase (EC 22.214.171.124) from Clostridium acetobutylicum.
Matsubara Y., Indo Y., Naito E., Ozasa H., Glassberg R., Vockley J., Ikeda Y., Kraus J., Tanaka K.
Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family.
Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein.
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