To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
PROSITE documentation PDOC00084

Ribonucleotide reductase large subunit signature


Ribonucleotide reductase (EC [1,2] catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. Ribonucleotide reductase is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues). There are regions of similarities in the sequence of the large chain from prokaryotes, eukaryotes and viruses. We have selected one of these regions as a signature pattern.

Last update:

December 2001 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBORED_LARGE, PS00089; Ribonucleotide reductase large subunit signature  (PATTERN)


1AuthorsNillson O., Lundqvist T., Hahne S., Sjoberg B.-M.
SourceBiochem. Soc. Trans. 16:91-94(1988).

2AuthorsReichard P.
TitleFrom RNA to DNA, why so many ribonucleotide reductases?
SourceScience 260:1773-1777(1993).
PubMed ID8511586

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)