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Ribonucleotide reductase (EC 184.108.40.206) [1,2] catalyzes the reductive synthesis
of deoxyribonucleotides from their corresponding ribonucleotides. It provides
the precursors necessary for DNA synthesis. Ribonucleotide reductase is an
oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a
small subunit (300 to 400 residues). There are regions of similarities in the
sequence of the large chain from prokaryotes, eukaryotes and viruses. We have
selected one of these regions as a signature pattern.
December 2001 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
Nillson O., Lundqvist T., Hahne S., Sjoberg B.-M.
Biochem. Soc. Trans. 16:91-94(1988).
From RNA to DNA, why so many ribonucleotide reductases?
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