PROSITE documentation PDOC00084

Ribonucleotide reductase large subunit signature

Description

Ribonucleotide reductase (EC 1.17.4.1) [1,2] catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. Ribonucleotide reductase is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues). There are regions of similarities in the sequence of the large chain from prokaryotes, eukaryotes and viruses. We have selected one of these regions as a signature pattern.

Last update:

December 2001 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBORED_LARGE, PS00089; Ribonucleotide reductase large subunit signature  (PATTERN)
Consensus pattern: W-x(2)-[LIVF]-x(6,7)-G-[LIVM]-[FYRA]-[NH]-x(3)-[STAQLIVM]-[ASC]-x(2)-[PA]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: 7
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• Scan Swiss-Prot/TrEMBL entries against PS00089
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Matching PDB structures: 1PEM 1PEO 1PEQ 1PEU ... [ALL]

References

1 Authors Nillson O., Lundqvist T., Hahne S., Sjoberg B.-M.
Source Biochem. Soc. Trans. 16:91-94(1988).
2 Authors Reichard P.
Title From RNA to DNA, why so many ribonucleotide reductases?
Source Science 260:1773-1777(1993).
PubMed ID 8511586

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