|PROSITE documentation PDOC00084
Ribonucleotide reductase large subunit signature
Ribonucleotide reductase (EC 22.214.171.124) [1,2] catalyzes the reductive synthesis
of deoxyribonucleotides from their corresponding ribonucleotides. It provides
the precursors necessary for DNA synthesis. Ribonucleotide reductase is an
oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a
small subunit (300 to 400 residues). There are regions of similarities in the
sequence of the large chain from prokaryotes, eukaryotes and viruses. We have
selected one of these regions as a signature pattern.
December 2001 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|RIBORED_LARGE, PS00089; Ribonucleotide reductase large subunit signature (PATTERN)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS00089:
||74 true positives with 4 false negatives.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00089:
||13 false positives.
|Matching PDB structures:
1PEM 1PEO 1PEQ 1PEU ... [ALL]
||Nillson O., Lundqvist T., Hahne S., Sjoberg B.-M.
||Biochem. Soc. Trans. 16:91-94(1988).
||From RNA to DNA, why so many ribonucleotide reductases?
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