{PDOC00084}
{PS00089; RIBORED_LARGE}
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* Ribonucleotide reductase large subunit signature *
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Ribonucleotide reductase (EC 1.17.4.1) [1,2] catalyzes the reductive synthesis
of deoxyribonucleotides from their  corresponding ribonucleotides. It provides
the precursors necessary  for  DNA synthesis.   Ribonucleotide reductase is an
oligomeric enzyme  composed of a  large  subunit (700 to 1000 residues)  and a
small subunit (300 to 400 residues).  There are regions of similarities in the
sequence of the large chain from prokaryotes, eukaryotes and viruses.  We have
selected one of these regions as a signature pattern.

-Consensus pattern: W-x(2)-[LIVF]-x(6,7)-G-[LIVM]-[FYRA]-[NH]-x(3)-[STAQLIVM]-
                    [ASC]-x(2)-[PA]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 7.
-Last update: December 2001 / Pattern and text revised.

[ 1] Nillson O., Lundqvist T., Hahne S., Sjoberg B.-M.
     Biochem. Soc. Trans. 16:91-94(1988).
[ 2] Reichard P.
     "From RNA to DNA, why so many ribonucleotide reductases?"
     Science 260:1773-1777(1993).
     PubMed=8511586

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