|PROSITE documentation PDOC00164
Phosphoribosylglycinamide synthetase signature
Phosphoribosylglycinamide synthetase (EC 126.96.36.199) (GARS) (phosphoribosylamine
glycine ligase)  catalyzes the second step in the de novo biosynthesis of
purine, the ATP-dependent addition of 5-phosphoribosylamine to glycine to
In bacteria GARS is a monofunctional enzyme (encoded by the purD gene), in
yeast it is part, with phosphoribosylformylglycinamidine cyclo-ligase (AIRS)
of a bifunctional enzyme (encoded by the ADE5,7 gene), in higher eukaryotes it
is part, with AIRS and with phosphoribosylglycinamide formyltransferase (GART)
of a trifunctional enzyme (GARS-AIRS-GART).
The sequence of GARS is well conserved. As a signature pattern we selected a
highly conserved octapeptide.
December 2001 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|GARS, PS00184; Phosphoribosylglycinamide synthetase signature (PATTERN)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS00184:
||108 true positives with 7 false negatives.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00184:
||1 false positive.
|Matching PDB structures:
1VKZ 2QK4 2XCL 2XD4 ... [ALL]
||Aiba A., Mizobuchi K.
||Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli.
||J. Biol. Chem. 264:21239-21246(1989).
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