|PROSITE documentation PDOC00164|
Phosphoribosylglycinamide synthetase (EC 220.127.116.11) (GARS) (phosphoribosylamine glycine ligase)  catalyzes the second step in the de novo biosynthesis of purine, the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide.
In bacteria GARS is a monofunctional enzyme (encoded by the purD gene), in yeast it is part, with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) of a bifunctional enzyme (encoded by the ADE5,7 gene), in higher eukaryotes it is part, with AIRS and with phosphoribosylglycinamide formyltransferase (GART) of a trifunctional enzyme (GARS-AIRS-GART).
The sequence of GARS is well conserved. As a signature pattern we selected a highly conserved octapeptide.
December 2001 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|GARS, PS00184; Phosphoribosylglycinamide synthetase signature (PATTERN)|
|Matching PDB structures: 1VKZ 2QK4 2XCL 2XD4 ... [ALL]|
|1||Authors||Aiba A., Mizobuchi K.|
|Title||Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli.|
|Source||J. Biol. Chem. 264:21239-21246(1989).|