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	PROSITE documentation PDOC00290

Tropomyosins [1,2] are family of closely related proteins present in muscle and non-muscle cells. In striated muscle, tropomyosin mediate the interactions between the troponin complex and actin so as to regulate muscle contraction. The role of tropomyosin in smooth muscle and non-muscle tissues is not clear. Tropomyosin is an α-helical protein that forms a coiled-coil dimer.

Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.

The signature pattern for tropomyosins is based on a very conserved region in the C-terminal section of tropomyosins and which is present in both muscle and non-muscle forms.

Last update:

December 2004 / Pattern and text revised.

PROSITE method (with tools and information) covered by this documentation:

TROPOMYOSIN, PS00326; Tropomyosins signature  (PATTERN)

• Consensus pattern:
  L-K-[EAD]-A-E-x-R-A-[ET]
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 83
  • detected by PS00326: 71 (true positives)
  • undetected by PS00326: 12 (11 false negatives and 1 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00326:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00326
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00326
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00326
• View ligand binding statistics of PS00326
• Matching PDB structures: 1C1G 2D3E 2EFR 2EFS ... [ALL]

1	Authors	Smilie L.B.
	Source	Trends Biochem. Sci. 4:151-155(1979).

2	Authors	McLeod A.R.
	Source	BioEssays 6:208-212(1986).

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