A number of transcription factors contain a conserved domain of 56 amino-acid
residues, sometimes known as the MADS-box domain. They are listed below:
Serum response factor (SRF) , a mammalian transcription factor that
binds to the Serum Response Element (SRE). This is a short sequence of dyad
symmetry located 300 bp to the 5' end of the transcription initiation site
of genes such as c-fos.
Mammalian myocyte-specific enhancer factors 2A to 2D (MEF2A to MEF2D).
These proteins are transcription factor which binds specifically to the
MEF2 element present in the regulatory regions of many muscle-specific
Yeast GRM/PRTF protein (gene MCM1) , a transcriptional regulator of
Yeast arginine metabolism regulation protein I (gene ARGR1 or ARG80).
Yeast transcription factor RLM1.
Yeast transcription factor SMP1.
Arabidopsis thaliana agamous protein (AG) , a probable transcription
factor involved in regulating genes that determines stamen and carpel
development in wild-type flowers. Mutations in the AG gene result in the
replacement of the stamens by petals and the carpels by a new flower.
Arabidopsis thaliana homeotic proteins Apetala1 (AP1), Apetala3 (AP3) and
Pistillata (PI) which act locally to specify the identity of the floral
meristem and to determine sepal and petal development .
Antirrhinum majus and tobacco homeotic protein deficiens (DEFA) and globosa
(GLO) . Both proteins are transcription factors involved in the genetic
control of flower development. Mutations in DEFA or GLO cause the
transformation of petals into sepals and of stamina into carpels.
Arabidopsis thaliana putative transcription factors AGL1 to AGL6 .
Antirrhinum majus morphogenetic protein DEF H33 (squamosa).
In SRF, the conserved domain has been shown  to be involved in DNA-binding
and dimerization. We have derived a pattern that spans the complete length of
the domain. The profile also spans the length of the MADS-box.
April 2006 / Pattern revised.
PROSITE methods (with tools and information) covered by this documentation:
Norman C., Runswick M., Pollock R., Treisman R.
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.