{PDOC00321}
{PS00379; CDP_ALCOHOL_P_TRANSF}
{BEGIN}
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* CDP-alcohol phosphatidyltransferases signature *
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A number of  phosphatidyltransferases,  which are all involved in phospholipid
biosynthesis and that share the property of catalyzing the displacement of CMP
from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond
and concomitant  breaking  of  a phosphoride  anhydride bond share a conserved
sequence region [1,2]. These enzymes are:

 - Ethanolaminephosphotransferase (EC 2.7.8.1) from yeast (gene EPT1).
 - Diacylglycerol  cholinephosphotransferase  (EC 2.7.8.2)  from  yeast  (gene
   CPT1).
 - Phosphatidylglycerophosphate synthase  (EC 2.7.8.5)   (CDP-diacylglycerol--
   glycerol-3-phosphate 3-phosphatidyltransferase) from bacteria (gene pgsA).
 - Phosphatidylserine synthase  (EC 2.7.8.8)    (CDP-diacylglycerol--serine O-
   phosphatidyltransferase) from  yeast (gene CHO1) and from Bacillus subtilis
   (gene pssA).
 - Phosphatidylinositol synthase  (EC 2.7.8.11)  (CDP-diacylglycerol--inositol
   3-phosphatidyltransferase) from yeast (gene PIS).

These  enzymes  are  proteins  of  from  200  to 400 amino acid residues.  The
conserved region contains  three aspartic  acid residues and is located in the
N-terminal section of the sequences.

-Consensus pattern: D-G-x(2)-A-R-x(7,8)-G-x(3)-D-x(3)-D
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Nikawa J.-I., Kodaki T., Yamashita S.
     "Primary structure and disruption of the phosphatidylinositol synthase
     gene of Saccharomyces cerevisiae."
     J. Biol. Chem. 262:4876-4881(1987).
     PubMed=3031032
[ 2] Hjelmstad R.H., Bell R.M.
     "sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in
     Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and
     comparison of the CPT1 and EPT1 gene products."
     J. Biol. Chem. 266:5094-5103(1991).
     PubMed=1848238

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