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	PROSITE documentation PDOC00339

The 43 Kd postsynaptic protein [1,2] is a peripheral membrane protein thought to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying post-synaptic cytoskeleton, possibly by direct association with actin or spectrin.

The 43 Kd protein is highly conserved across species. Two highly conserved regions, one encompassing the N-terminus and the other near the C-terminus, may be important for interaction of the protein with other components of the postsynaptic membrane.

As a signature pattern we selected the N-terminus of the mature protein (after removal of the initiator methionine). The N-terminal glycine is thought to be myristoylated.

Last update:

November 1990 / First entry.

PROSITE method (with tools and information) covered by this documentation:

43_KD_POSTSYNAPTIC, PS00405; 43 Kd postsynaptic protein signature  (PATTERN)

• Consensus pattern:
  G-Q-D-Q-T-K-Q-Q-I
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 4
  • detected by PS00405: 4 (true positives)
  • undetected by PS00405: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00405:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00405
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00405
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00405
• View ligand binding statistics of PS00405

1	Authors	Froehner S.C.
	Source	Trends Neurosci. 9:37-41(1986).

2	Authors	Froehner S.C.
	Title	Expression of RNA transcripts for the postsynaptic 43 kDa protein in innervated and denervated rat skeletal muscle.
	Source	FEBS Lett. 249:229-233(1989).
	PubMed ID	2737281

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