|PROSITE documentation PDOC00359
UDP glycosyltransferases (UGT) are a superfamily of enzymes that catalyzes the
addition of the glycosyl group from a UTP-sugar to a small hydrophobic
molecule. This family currently consist of:
- Mammalian UDP-glucoronosyl transferases (EC 188.8.131.52) (UDPGT) [1,2]. A
large family of membrane-bound microsomal enzymes which catalyze the
transfer of glucuronic acid to a wide variety of exogenous and endogenous
lipophilic substrates. These enzymes are of major importance in the
detoxification and subsequent elimination of xenobiotics such as drugs and
- A large number of putative UDPGT from Caenorhabditis elegans.
- Mammalian 2-hydroxyacylsphingosine 1-β-galactosyltransferase 
(EC 184.108.40.206) (also known as UDP-galactose-ceramide galactosyltransferase).
This enzyme catalyzes the transfer of galactose to ceramide, a key
enzymatic step in the biosynthesis of galactocerebrosides, which are
abundant sphingolipids of the myelin membrane of the central nervous system
and peripheral nervous system.
- Plants flavonol O(3)-glucosyltransferase (EC 220.127.116.11). An enzyme  that
catalyzes the transfer of glucose from UDP-glucose to a flavanol. This
reaction is essential and one of the last steps in anthocyanin pigment
- Plants limonoid glucosyltransferase (EC 18.104.22.168).
- Baculoviruses ecdysteroid UDP-glucosyltransferase (EC 2.4.1.-)  (egt).
This enzyme catalyzes the transfer of glucose from UDP-glucose to
ectysteroids which are insect molting hormones. The expression of egt in
the insect host interferes with the normal insect development by blocking
the molting process.
- Prokaryotic zeaxanthin glucosyl transferase (EC 2.4.1.-) (gene crtX), an
enzyme involved in carotenoid biosynthesis and that catalyses the
glycosylation reaction which converts zeaxanthin to zeaxanthin-β-
- Streptomyces macrolide glycosyltransferases (EC 2.4.1.-) . These enzymes
specifically inactivates macrolide anitibiotics via 2'-O-glycosylation
These enzymes share a conserved domain of about 50 amino acid residues located
in their C-terminal section and from which a pattern has been extracted to
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|UDPGT, PS00375; UDP-glycosyltransferases signature (PATTERN)
|Sequences known to belong to this class detected by the pattern:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
2C1X 2C1Z 2C9Z 2IYF ... [ALL]
||(In) Glucoronidation of drugs and other compounds, Dutton G.J., Ed., pp 1-78, CRC Press, Boca Raton, (1980).
||Burchell B., Nebert D.W., Nelson D.R., Bock K.W., Iyanagi T., Jansen P.L., Lancet D., Mulder G.J., Chowdhury J.R., Siest G., Tephly T.R., Mackenzie P.I.
||DNA Cell Biol. 10:487-494(1991).
||Schulte S., Stoffel W.
||Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression.
||Proc. Natl. Acad. Sci. U.S.A. 90:10265-10269(1993).
||Furtek D., Schiefelbein J.W., Johnston F., Nelson O.E. Jr.
||Plant Mol. Biol. 11:473-481(1988).
||O'Reilly D.R., Miller L.K.
||Hernandez C., Olano C., Mendez C., Salas J.A.
||Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation.
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