PROSITE documentation PDOC00362

Dynamin family signature




Description

Dynamin [1,2] is a microtubule-associated force-producing protein of 100 Kd which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Dynamin is structurally related to the following proteins:

  • Drosophila shibire protein (gene shi) [3]. Shibire is, very probably, the Drosophila cognate of mammalian dynamin. It seems to provide the motor for vesicular transport during endocytosis.
  • Yeast vacuolar sorting protein VPS1 (or SPO15) [4], a protein which could also be involved in microtubule-associated motility.
  • Yeast protein MGM1 [5], which is required for mitochondrial genome maintenance.
  • Yeast protein DNM1, which is involved in endocytosis.
  • Interferon induced Mx proteins [6,7]. Interferon α or β induce the synthesis of a family of closely related proteins. Most of these proteins are known to confer resistance to influenza viruses and/or rhabdoviruses on transfected mammalian cell in culture.

The three motifs found in all GTP-binding proteins are located in the N-terminal part of these proteins. The signature pattern that we developed for these proteins is based on a highly conserved region downstream of the ATP/GTP-binding motif 'A' (P-loop) (see <PDOC00017>).

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

DYNAMIN, PS00410; Dynamin family signature  (PATTERN)


References

1AuthorsVallee R.B., Shpetner H.S.
TitleMotor proteins of cytoplasmic microtubules.
SourceAnnu. Rev. Biochem. 59:909-932(1990).
PubMed ID2142876
DOI10.1146/annurev.bi.59.070190.004401

2AuthorsObar R.A., Collins C.A., Hammarback J.A., Shpetner H.S., Vallee R.B.
TitleMolecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins.
SourceNature 347:256-261(1990).
PubMed ID2144893
DOI10.1038/347256a0

3Authorsvan der Bliek A., Meyerowitz E.M.
SourceNature 351:411-414(1991).

4AuthorsRothman J.H., Raymond C.K., Gilbert T., O'Hara P.J., Stevens T.H.
TitleA putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting.
SourceCell 61:1063-1074(1990).
PubMed ID2112425

5AuthorsJones B.A., Fangman W.L.
TitleMitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin.
SourceGenes Dev. 6:380-389(1992).
PubMed ID1532158

6AuthorsArnheiter H., Meier E.
TitleMx proteins: antiviral proteins by chance or by necessity?
SourceNew Biol. 2:851-857(1990).
PubMed ID1706623

7AuthorsStaeheli P., Pitossi F., Pavlovic J.
TitleMx proteins: GTPases with antiviral activity.
SourceTrends Cell Biol. 3:268-272(1993).
PubMed ID14731745



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