Dynamin [1,2] is a microtubule-associated force-producing protein of 100 Kd
which is involved in the production of microtubule bundles and which is able
to bind and hydrolyze GTP. Dynamin is structurally related to the following
Drosophila shibire protein (gene shi) . Shibire is, very probably, the
Drosophila cognate of mammalian dynamin. It seems to provide the motor for
vesicular transport during endocytosis.
Yeast vacuolar sorting protein VPS1 (or SPO15) , a protein which could
also be involved in microtubule-associated motility.
Yeast protein MGM1 , which is required for mitochondrial genome
Yeast protein DNM1, which is involved in endocytosis.
Interferon induced Mx proteins [6,7]. Interferon α or β induce the
synthesis of a family of closely related proteins. Most of these proteins
are known to confer resistance to influenza viruses and/or rhabdoviruses on
transfected mammalian cell in culture.
The three motifs found in all GTP-binding proteins are located in the N-terminal part of these proteins. The signature pattern that we developed for
these proteins is based on a highly conserved region downstream of the
ATP/GTP-binding motif 'A' (P-loop) (see <PDOC00017>).
April 2006 / Pattern revised.
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