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Dynamin [1,2] is a microtubule-associated force-producing protein of 100 Kd which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Dynamin is structurally related to the following proteins:

• Drosophila shibire protein (gene shi) [3]. Shibire is, very probably, the Drosophila cognate of mammalian dynamin. It seems to provide the motor for vesicular transport during endocytosis.
• Yeast vacuolar sorting protein VPS1 (or SPO15) [4], a protein which could also be involved in microtubule-associated motility.
• Yeast protein MGM1 [5], which is required for mitochondrial genome maintenance.
• Yeast protein DNM1, which is involved in endocytosis.
• Interferon induced Mx proteins [6,7]. Interferon α or β induce the synthesis of a family of closely related proteins. Most of these proteins are known to confer resistance to influenza viruses and/or rhabdoviruses on transfected mammalian cell in culture.

The three motifs found in all GTP-binding proteins are located in the N-terminal part of these proteins. The signature pattern that we developed for these proteins is based on a highly conserved region downstream of the ATP/GTP-binding motif 'A' (P-loop) (see <PDOC00017>).

April 2006 / Pattern revised.

PROSITE method (with tools and information) covered by this documentation:

DYNAMIN, PS00410; Dynamin family signature  (PATTERN)

Consensus pattern: L-P-[RKT]-[GD]-[STNKEA]-[GND]-[LIVMG]-[VICA]-T-R Sequences known to belong to this class detected by the pattern: ALL Other sequence(s) detected in Swiss-Prot: NONE

• Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00410 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00410 • Scan Swiss-Prot/TrEMBL entries against PS00410 • view ligand binding statistics

Matching PDB structures: 2AKA 2X2E 2X2F 3T34 ... [ALL]

1	Authors	Vallee R.B., Shpetner H.S.
	Title	Motor proteins of cytoplasmic microtubules.
	Source	Annu. Rev. Biochem. 59:909-932(1990).
	PubMed ID	2142876
	DOI	10.1146/annurev.bi.59.070190.004401

2	Authors	Obar R.A., Collins C.A., Hammarback J.A., Shpetner H.S., Vallee R.B.
	Title	Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins.
	Source	Nature 347:256-261(1990).
	PubMed ID	2144893
	DOI	10.1038/347256a0

3	Authors	van der Bliek A., Meyerowitz E.M.
	Source	Nature 351:411-414(1991).

4	Authors	Rothman J.H., Raymond C.K., Gilbert T., O'Hara P.J., Stevens T.H.
	Title	A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting.
	Source	Cell 61:1063-1074(1990).
	PubMed ID	2112425

5	Authors	Jones B.A., Fangman W.L.
	Title	Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin.
	Source	Genes Dev. 6:380-389(1992).
	PubMed ID	1532158

6	Authors	Arnheiter H., Meier E.
	Title	Mx proteins: antiviral proteins by chance or by necessity?
	Source	New Biol. 2:851-857(1990).
	PubMed ID	1706623

7	Authors	Staeheli P., Pitossi F., Pavlovic J.
	Title	Mx proteins: GTPases with antiviral activity.
	Source	Trends Cell Biol. 3:268-272(1993).
	PubMed ID	14731745

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