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PROSITE documentation PDOC00385

Ribosomal protein L3 signature

Description:

Ribosomal protein L3 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L3 is known to bind to the 23S rRNA and may participate in the formation of the peptidyltransferase center of the ribosome. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2,3,4], groups:

  • Eubacterial L3.
  • Red algal L3.
  • Cyanelle L3.
  • Archaebacterial Halobacterium marismortui HmaL3 (HL1).
  • Yeast L3 (also known as trichodermin resistance protein) (gene TCM1).
  • Arabidopsis thaliana L3 (genes ARP1 and ARP2).
  • Mammalian L3 (L4).
  • Mammalian mitochondrial L3.
  • Yeast mitochondrial YmL9 (gene MRPL9).

As a signature pattern, we selected a conserved region located in the central section of these proteins.

Last update:

November 1997 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L3, PS00474; Ribosomal protein L3 signature  (PATTERN)
Consensus pattern: [FL]-x(6)-[DN]-x(2)-[AGS]-x-[ST]-x-G-[KRH]-G-x(2)-G-x(3)-R
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00474
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00474
• Scan Swiss-Prot/TrEMBL entries against PS00474
• view ligand binding statistics
Matching PDB structures: 1FFK 1GIY 1JJ2 1K5Y ... [ALL]

References:

1 AuthorsArndt E., Kroemer W., Hatakeyama T.
TitleOrganization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui.
SourceJ. Biol. Chem. 265:3034-3039(1990).
PubMed ID2406244
2 AuthorsGraack H.-R., Grohmann L., Kitakawa M., Schaefer K.L., Kruft V.
TitleYmL9, a nucleus-encoded mitochondrial ribosomal protein of yeast, is homologous to L3 ribosomal proteins from all natural kingdoms and photosynthetic organelles.
SourceEur. J. Biochem. 206:373-380(1992).
PubMed ID1597181
3 AuthorsHerwig S., Kruft V., Wittmann-Liebold B.
TitlePrimary structures of ribosomal proteins L3 and L4 from Bacillus stearothermophilus.
SourceEur. J. Biochem. 207:877-885(1992).
PubMed ID1499563
4 AuthorsOtaka E., Hashimoto T., Mizuta K., Suzuki K.
SourceProtein Seq. Data Anal. 5:301-313(1993).

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