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PROSITE documentation PDOC00386

Ribosomal protein L15 signature

Description:

Ribosomal protein L15 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L15 is known to bind the 23S rRNA. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1], groups:

  • Eubacterial L15.
  • Plant chloroplast L15 (nuclear-encoded).
  • Archaebacterial L15.
  • Vertebrate L27a.
  • Tetrahymena thermophila L29.
  • Fungi L27a (L29, CRP-1, CYH2).

L15 is a protein of 144 to 154 amino-acid residues. As a signature pattern, we selected a conserved region in the C-terminal section of these proteins.

Last update:

April 2006 / Pattern revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L15, PS00475; Ribosomal protein L15 signature  (PATTERN)
Consensus pattern: [KR]-[LIVM](2)-[GASL]-x-[GT]-x-[LIVMA]-x(2,5)-[LIVMF]-x-[LIVMF]-x(3,4)-[LIVMFCA]-[ST]-x(2)-A-x(3)-[LIVM]-x(3)-G
Sequences known to belong to this class detected by the pattern: ALL, except for Chlamydia trachomatis, H.pylori and Mycoplasma genitalium L15
Other sequence(s) detected in Swiss-Prot: archebacterial ribosomal proteins from the L18e family
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00475
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00475
• Scan Swiss-Prot/TrEMBL entries against PS00475
• view ligand binding statistics
Matching PDB structures: 1FFK 1GIY 1GS2 1JJ2 ... [ALL]

Reference:

1 AuthorsOtaka E., Hashimoto T., Mizuta K., Suzuki K.
SourceProtein Seq. Data Anal. 5:301-313(1993).

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