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| PROSITE documentation PDOC00390 |
6-phosphogluconate dehydrogenase signature
Description:
6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step
in the hexose monophosphate shunt, the decarboxylating reduction of
6-phosphogluconate in to ribulose 5-phosphate.
Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose
sequence are highly conserved [1]. As a signature pattern we have selected a
region which has been shown [2], from studies of the sheep 6PGD tertiary
structure, to be involved in the binding of 6-phosphogluconate.
Last update:
December 2004 / Pattern and text revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| 6PGD, PS00461; 6-phosphogluconate dehydrogenase signature (PATTERN) |
| Consensus pattern: |
[LIVM]-x-[DG]-x(2)-[GAEHS]-[NQSD]-[KS]-G-[TE]-G-x-W
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
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| Matching PDB structures:
1PGJ 1PGN 1PGO 1PGP ... [ALL] |
References:
| 1 |
Authors | Reizer A., Deutscher J., Saier M.H. Jr., Reizer J. |
| Title | Analysis of the gluconate (gnt) operon of Bacillus subtilis. |
| Source | Mol. Microbiol. 5:1081-1089(1991). |
| PubMed ID | 1659648 |
| 2 |
Authors | Adams M.J., Archibald I.G., Bugg C.E., Carne A., Gover S., Helliwell J.R., Pickersgill R.W., White S.W. |
| Title | The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. |
| Source | EMBO J. 2:1009-1014(1983). |
| PubMed ID | 6641716 |
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