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	PROSITE documentation PDOC00390

6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.

Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [1]. As a signature pattern we have selected a region which has been shown [2], from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.

Last update:

December 2004 / Pattern and text revised.

PROSITE method (with tools and information) covered by this documentation:

6PGD, PS00461; 6-phosphogluconate dehydrogenase signature  (PATTERN)

• Consensus pattern:
  [LIVM]-x-[DG]-x(2)-[GAEHS]-[NQSD]-[KS]-G-[TE]-G-x-W
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 64
  • detected by PS00461: 56 (true positives)
  • undetected by PS00461: 8 (8 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00461:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00461
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00461
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00461
• View ligand binding statistics of PS00461
• Matching PDB structures: 1PGJ 1PGN 1PGO 1PGP ... [ALL]

1	Authors	Reizer A., Deutscher J., Saier M.H. Jr., Reizer J.
	Title	Analysis of the gluconate (gnt) operon of Bacillus subtilis.
	Source	Mol. Microbiol. 5:1081-1089(1991).
	PubMed ID	1659648

2	Authors	Adams M.J., Archibald I.G., Bugg C.E., Carne A., Gover S., Helliwell J.R., Pickersgill R.W., White S.W.
	Title	The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.
	Source	EMBO J. 2:1009-1014(1983).
	PubMed ID	6641716

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