|PROSITE documentation PDOC00390|
6-phosphogluconate dehydrogenase (EC 220.127.116.11) (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.
Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved . As a signature pattern we have selected a region which has been shown , from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.Last update:
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Reizer A., Deutscher J., Saier M.H. Jr., Reizer J.|
|Title||Analysis of the gluconate (gnt) operon of Bacillus subtilis.|
|Source||Mol. Microbiol. 5:1081-1089(1991).|
|2||Authors||Adams M.J., Archibald I.G., Bugg C.E., Carne A., Gover S., Helliwell J.R., Pickersgill R.W., White S.W.|
|Title||The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.|
|Source||EMBO J. 2:1009-1014(1983).|