Peroxisomal carnitine octanoyltransferase (EC 2.3.1.-) (COT), a fatty acid
β-oxidation pathway enzyme which is involved in the transport of medium-
chain acyl-coenzyme A's from peroxisome to mitochondria .
Mitochondrial carnitine O-palmitoyltransferases I and II (EC 126.96.36.199)
(CPT), enzymes involved in fatty acid metabolism and transport .
These enzymes share many regions of sequence similarities. As signature
patterns we selected two of these regions. The first one, located in the
N-terminal section of these enzymes is characterized by the presence of three
[LIVM]-P dipeptides. The second region, located in the central part of these
enzymes is characterized by the conservation of a number of charged residues
including an histidine which probably plays a crucial role in the catalytic
December 2004 / Patterns and text revised.
PROSITE methods (with tools and information) covered by this documentation:
Berrard S., Brice A., Lottspeich F., Braun A., Barde Y.-A., Mallet J.
cDNA cloning and complete sequence of porcine choline acetyltransferase: in vitro translation of the corresponding RNA yields an active protein.
Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.