PROSITE documentation PDOC00408

FGGY family of carbohydrate kinases signatures

Description

It has been shown [1] that four different type of carbohydrate kinases seem to be evolutionary related. These enzymes are:

  • L-fuculokinase (EC 2.7.1.51) (gene fucK).
  • Gluconokinase (EC 2.7.1.12) (gene gntK).
  • Glycerokinase (EC 2.7.1.30) (gene glpK).
  • Xylulokinase (EC 2.7.1.17) (gene xylB).
  • L-xylulose kinase (EC 2.7.1.53) (gene lyxK).

These enzymes are proteins of from 480 to 520 amino acid residues.

As consensus patterns for this family of kinases we selected two conserved regions, one in the central section, the other in the C-terminal section.

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

FGGY_KINASES_1, PS00933; FGGY family of carbohydrate kinases signature 1  (PATTERN)
Consensus pattern: [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-{G}-W-[LIVMF]-{E}-[DENQTKR]-[ENQH]
Sequences known to belong to this class detected by the pattern: ALL, except for lyxK
Other sequence(s) detected in Swiss-Prot: 5.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00933
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00933
• Scan Swiss-Prot/TrEMBL entries against PS00933
• view ligand binding statistics
Matching PDB structures: 1BO5 1BOT 1BU6 1BWF ... [ALL]
FGGY_KINASES_2, PS00445; FGGY family of carbohydrate kinases signature 2  (PATTERN)
Consensus pattern: [GSA]-x-[LIVMFYW]-{D}-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-{PEQ}-{DTAI}-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: 20.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00445
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00445
• Scan Swiss-Prot/TrEMBL entries against PS00445
• view ligand binding statistics
Matching PDB structures: 1BO5 1BOT 1BU6 1BWF ... [ALL]

Reference

1 Authors Reizer A., Deutscher J., Saier M.H. Jr., Reizer J.
Title Analysis of the gluconate (gnt) operon of Bacillus subtilis.
Source Mol. Microbiol. 5:1081-1089(1991).
PubMed ID 1659648

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