{PDOC00429}
{PS00456; NA_SOLUT_SYMP_1}
{PS00457; NA_SOLUT_SYMP_2}
{PS50283; NA_SOLUT_SYMP_3}
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* Sodium:solute symporter family signatures and profile *
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It has    been  shown  [1,2]  that integral membrane proteins that mediate the
intake of a wide variety  of  molecules  with the concomitant uptake of sodium
ions (sodium  symporters)  can  be  grouped,  on  the  basis  of  sequence and
functional similarities  into  a  number  of  distinct  families. One of these
families is  known as the  sodium:solute  symporter family (SSF) and currently
consists of the following proteins:

 - Mammalian Na+/glucose co-transporter.
 - Mammalian Na+/myo-inositol co-transporter.
 - Mammalian Na+/nucleoside co-transporter.
 - Mammalian Na+/neutral amino acid co-transporter.
 - Mammalian Na+/iodide co-transporter.
 - Mammalian Na+/multivitamin co-transporter.
 - Escherichia coli Na+/proline symporter (gene putP).
 - Escherichia coli Na+/pantothenate symporter (gene panF).
 - Escherichia coli hypothetical protein yidK.
 - Escherichia coli hypothetical protein yjcG.
 - Bacillus subtilis hypothetical protein ywcA (ipa-31R).

These integral  membrane  proteins  are  predicted  to  comprise  at least ten
membrane spanning  domains.  As  signature  patterns we selected two conserved
regions; the  first  one is located in the fourth transmembrane region and the
second one  in a loop between two transmembrane regions in the C-terminal part
of these proteins.

-Consensus pattern: [GS]-x(2)-[LIY]-x(3)-[LIVMFYWSTAG](7)-x(3)-[LIY]-[STAV]-
                    x(2)-G-G-[LMF]-x-[SAP]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 1.

-Consensus pattern: [GAST]-[LIVM]-x(3)-[KR]-x(4)-G-A-x(2)-[GAS]-[LIVMGS]-
                    [LIVMW]-[LIVMGAT]-G-x-[LIVMGA]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for E.coli yidK.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2001 / Patterns and text revised; profile added.

[ 1] Reizer J., Reizer A., Saier M.H. Jr.
     "The Na+/pantothenate symporter (PanF) of Escherichia coli is
     homologous to the Na+/proline symporter (PutP) of E. coli and the
     Na+/glucose symporters of mammals."
     Res. Microbiol. 141:1069-1072(1990).
     PubMed=1965458
[ 2] Reizer J., Reizer A., Saier M.H. Jr.
     "A functional superfamily of sodium/solute symporters."
     Biochim. Biophys. Acta 1197:133-166(1994).
     PubMed=8031825

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