|PROSITE documentation PDOC00441
Malate synthase signature
Malate synthase (EC 18.104.22.168) catalyzes the aldol condensation of glyoxylate
with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an
alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.
Malate synthase is a protein of 530 to 570 amino acids whose sequence is
highly conserved across species . As a signature pattern, we selected a
very conserved region in the central section of the enzyme.
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|MALATE_SYNTHASE, PS00510; Malate synthase signature (PATTERN)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS00510:
||21 true positives.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00510:
|Matching PDB structures:
3CUZ 3CV1 3CV2 [ALL]
||Bruinenberg P.G., Blaauw M., Kazemier B., Ab G.
||Cloning and sequencing of the malate synthase gene from Hansenula polymorpha.
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