|PROSITE documentation PDOC00441|
Malate synthase (EC 126.96.36.199) catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.
Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species . As a signature pattern, we selected a very conserved region in the central section of the enzyme.Last update:
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Bruinenberg P.G., Blaauw M., Kazemier B., Ab G.|
|Title||Cloning and sequencing of the malate synthase gene from Hansenula polymorpha.|