PROSITE documentation PDOC00441

Malate synthase signature


Malate synthase (EC catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.

Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [1]. As a signature pattern, we selected a very conserved region in the central section of the enzyme.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

MALATE_SYNTHASE, PS00510; Malate synthase signature  (PATTERN)


1AuthorsBruinenberg P.G., Blaauw M., Kazemier B., Ab G.
TitleCloning and sequencing of the malate synthase gene from Hansenula polymorpha.
SourceYeast 6:245-254(1990).
PubMed ID2349836

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)