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PROSITE documentation PDOC00441

Malate synthase signature

Description:

Malate synthase (EC 2.3.3.9) catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.

Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [1]. As a signature pattern, we selected a very conserved region in the central section of the enzyme.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

MALATE_SYNTHASE, PS00510; Malate synthase signature  (PATTERN)
Consensus pattern: [KR]-[DENQ]-[HN]-x(2)-G-L-N-x-G-x-W-D-Y-[LIVM]-F
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00510
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00510
• Scan Swiss-Prot/TrEMBL entries against PS00510
• view ligand binding statistics
Matching PDB structures: 3CUZ 3CV1 3CV2 [ALL]

Reference:

1 AuthorsBruinenberg P.G., Blaauw M., Kazemier B., Ab G.
TitleCloning and sequencing of the malate synthase gene from Hansenula polymorpha.
SourceYeast 6:245-254(1990).
PubMed ID2349836

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