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Malate synthase (EC 188.8.131.52) catalyzes the aldol condensation of glyoxylate
with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an
alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.
Malate synthase is a protein of 530 to 570 amino acids whose sequence is
highly conserved across species . As a signature pattern, we selected a
very conserved region in the central section of the enzyme.
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
Bruinenberg P.G., Blaauw M., Kazemier B., Ab G.
Cloning and sequencing of the malate synthase gene from Hansenula polymorpha.
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