{PDOC00441} {PS00510; MALATE_SYNTHASE} {BEGIN} ***************************** * Malate synthase signature * ***************************** Malate synthase (EC 2.3.3.9) catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [1]. As a signature pattern, we selected a very conserved region in the central section of the enzyme. -Consensus pattern: [KR]-[DENQ]-[HN]-x(2)-G-L-N-x-G-x-W-D-Y-[LIVM]-F -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. [ 1] Bruinenberg P.G., Blaauw M., Kazemier B., Ab G. "Cloning and sequencing of the malate synthase gene from Hansenula polymorpha." Yeast 6:245-254(1990). PubMed=2349836 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}