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Prokaryotic ribonuclease III (EC 3.1.26.3) (gene rnc) [1] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related [2] to the following proteins:

• Fission yeast pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development.
• Yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites.
• Caenorhabditis elegans hypothetical protein F26E4.13.
• Paramecium bursaria chlorella virus 1 protein A464R.
• Synechocystis strain PCC 6803 hypothetical protein slr0346.
• Fission yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain.
• Caenorhabditis elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c.

These proteins share regions of sequence similarity; one of which is a highly conserved stretch of 9 residues which we use as a signature pattern.

December 2004 / Pattern and text revised.

PROSITE methods (with tools and information) covered by this documentation:

RNASE_3_2, PS50142; Ribonuclease III family domain profile  (MATRIX)

Sequences known to belong to this class detected by the profile: ALL Other sequence(s) detected in Swiss-Prot: NONE.

• Domain architecture view of Swiss-Prot proteins matching PS50142 • Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS50142 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS50142 • Scan Swiss-Prot/TrEMBL entries against PS50142 • view ligand binding statistics

Matching PDB structures: 1I4S 1JFZ 1O0W 1RC5 ... [ALL]

RNASE_3_1, PS00517; Ribonuclease III family signature  (PATTERN)

Consensus pattern: [DEQ]-[KRQT]-[LMF]-E-[FYW]-[LV]-G-D-[SARHG] Sequences known to belong to this class detected by the pattern: ALL Other sequence(s) detected in Swiss-Prot: NONE.

• Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00517 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00517 • Scan Swiss-Prot/TrEMBL entries against PS00517 • view ligand binding statistics

Matching PDB structures: 1I4S 1JFZ 1O0W 1RC5 ... [ALL]

1	Authors	Nashimoto H., Uchida H.
	Title	DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations.
	Source	Mol. Gen. Genet. 201:25-29(1985).
	PubMed ID	3903434

2	Authors	Mian I.S.
	Title	Comparative sequence analysis of ribonucleases HII, III, II PH and D.
	Source	Nucleic Acids Res. 25:3187-3195(1997).
	PubMed ID	9241229

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