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PROSITE documentation PDOC00451

Delta 1-pyrroline-5-carboxylate reductase signature

Description:

Delta 1-pyrroline-5-carboxylate reductase (P5CR) (EC 1.5.1.2) [1,2] is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline.

The sequences of P5CR from eubacteria (gene proC), archaebacteria and eukaryotes show only a moderate level of overall similarity. As a signature pattern, we selected the best conserved region located in the C-terminal section of P5CR.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

P5CR, PS00521; Delta 1-pyrroline-5-carboxylate reductase signature  (PATTERN)
Consensus pattern: [PALF]-x(2,3)-[LIV]-x(3)-[LIVM]-[STAC]-[STV]-x-[GANK]-G-x-T-x(2)-[AG]-[LIV]-x(2)-[LMF]-[DENQK]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00521
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00521
• Scan Swiss-Prot/TrEMBL entries against PS00521
• view ligand binding statistics
Matching PDB structures: 2GER 2GR9 2GRA 2IZZ [ALL]

References:

1 AuthorsDelauney A.J., Verma D.P.
TitleA soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was isolated by functional complementation in Escherichia coli and is found to be osmoregulated.
SourceMol. Gen. Genet. 221:299-305(1990).
PubMed ID2199815
2 AuthorsSavioz A., Jeenes D.J., Kocher H.P., Haas D.
TitleComparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli.
SourceGene 86:107-111(1990).
PubMed ID2107123

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