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PROSITE documentation PDOC00457

Ribosomal protein S4e signature

Description:

A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of:

  • Mammalian S4 [1]. Two highly similar isoforms of this protein exist : one coded by a gene on chromosome Y, and the other on chromosome X.
  • Plant cytoplasmic S4 [2]
  • Yeast S7 (YS6).
  • Archebacterial S4e.

These proteins have 233 to 264 amino acids. As a signature pattern, we selected a highly conserved stretch of 15 residues in their N-terminal section. Four positions in this region are positively charged residues.

Last update:

July 1999 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S4E, PS00528; Ribosomal protein S4e signature  (PATTERN)
Consensus pattern: H-x-K-R-[LIVMF]-[SANK]-x-P-x(2)-[WY]-x-[LIVM]-x-[KRP]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00528
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00528
• Scan Swiss-Prot/TrEMBL entries against PS00528
• view ligand binding statistics
Matching PDB structures: 2XZM 2XZN [ALL]

References:

1 AuthorsFisher E.M., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
TitleHomologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.
SourceCell 63:1205-1218(1990).
PubMed ID2124517
2 AuthorsBraun H.P., Emmermann M., Mentzel H., Schmitz U.K.
TitlePrimary structure and expression of a gene encoding the cytosolic ribosomal protein S4 from potato.
SourceBiochim. Biophys. Acta 1218:435-438(1994).
PubMed ID8049269

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