{PDOC00457} {PS00528; RIBOSOMAL_S4E} {BEGIN} *********************************** * Ribosomal protein S4e signature * *********************************** A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of: - Mammalian S4 [1]. Two highly similar isoforms of this protein exist : one coded by a gene on chromosome Y, and the other on chromosome X. - Plant cytoplasmic S4 [2] - Yeast S7 (YS6). - Archebacterial S4e. These proteins have 233 to 264 amino acids. As a signature pattern, we selected a highly conserved stretch of 15 residues in their N-terminal section. Four positions in this region are positively charged residues. -Consensus pattern: H-x-K-R-[LIVMF]-[SANK]-x-P-x(2)-[WY]-x-[LIVM]-x-[KRP] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 1999 / Pattern and text revised. [ 1] Fisher E.M., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C. "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome." Cell 63:1205-1218(1990). PubMed=2124517 [ 2] Braun H.P., Emmermann M., Mentzel H., Schmitz U.K. "Primary structure and expression of a gene encoding the cytosolic ribosomal protein S4 from potato." Biochim. Biophys. Acta 1218:435-438(1994). PubMed=8049269 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}