The pyridine nucleotide-disulphide oxidoreductases are FAD flavoproteins which
contains a pair of redox-active cysteines involved in the transfer of reducing
equivalents from the FAD cofactor to the substrate. On the basis of sequence
and structural similarities  these enzymes can be classified into two
categories. The second category groups together the following enzymes:
Bacterial and fungal thioredoxin reductase (EC 220.127.116.11) (gene trxB) .
Salmonella typhimurium alkyl hydroperoxide reductase protein F52a (gene
aphF) , an enzyme that serves to protect the cell against damage to DNA
by alkyl hydroperoxides.
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