6-phosphofructokinase isozyme 2 (EC 126.96.36.199) (phosphofructokinase-2) (gene
pfkB). pfkB is a minor phosphofructokinase isozyme in Escherichia coli and
is not evolutionary related to the major isozyme (gene pfkA). Plants
6-phosphofructokinase also belong to this family.
All the above kinases are proteins of from 280 to 430 amino acid residues that
share a few region of sequence similarity. We have selected two of these
regions as signature patterns. The first pattern is based on a region rich
in glycine which is located in the N-terminal section of these enzymes; while
the second pattern is based on a conserved region in the C-terminal section.
Some bacterial fructokinases belong to the ROK family <PDOC00866>.
April 2006 / Pattern revised.
PROSITE methods (with tools and information) covered by this documentation:
Wu L.-F., Reizer A., Reizer J., Cai B., Tomich J.M., Saier M.H. Jr.
Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.