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| PROSITE documentation PDOC00504 |
pfkB family of carbohydrate kinases signatures
Description:
It has been shown [1,2,3] that the following carbohydrate and purine kinases
are evolutionary related and can be grouped into a single family, which is
known [1] as the 'pfkB family':
- Fructokinase (EC 2.7.1.4) (gene scrK).
- 6-phosphofructokinase isozyme 2 (EC 2.7.1.11) (phosphofructokinase-2) (gene
pfkB). pfkB is a minor phosphofructokinase isozyme in Escherichia coli and
is not evolutionary related to the major isozyme (gene pfkA). Plants
6-phosphofructokinase also belong to this family.
- Ribokinase (EC 2.7.1.15) (gene rbsK).
- Adenosine kinase (EC 2.7.1.20) (gene ADK).
- 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) (gene: kdgK).
- 1-phosphofructokinase (EC 2.7.1.56) (fructose 1-phosphate kinase) (gene
fruK).
- Inosine-guanosine kinase (EC 2.7.1.73) (gene gsk).
- Tagatose-6-phosphate kinase (EC 2.7.1.144) (phosphotagatokinase) (gene
lacC).
- Escherichia coli hypothetical protein yeiC.
- Escherichia coli hypothetical protein yeiI.
- Escherichia coli hypothetical protein yhfQ.
- Escherichia coli hypothetical protein yihV.
- Bacillus subtilis hypothetical protein yxdC.
- Yeast hypothetical protein YJR105w.
All the above kinases are proteins of from 280 to 430 amino acid residues that
share a few region of sequence similarity. We have selected two of these
regions as signature patterns. The first pattern is based on a region rich
in glycine which is located in the N-terminal section of these enzymes; while
the second pattern is based on a conserved region in the C-terminal section.
Note:
Some bacterial fructokinases belong to the ROK family <PDOC00866>.
Last update:
April 2006 / Pattern revised.
Technical section:
PROSITE methods (with tools and information) covered by this documentation:
| PFKB_KINASES_1, PS00583; pfkB family of carbohydrate kinases signature 1 (PATTERN) |
| Consensus pattern: |
[AG]-G-x(0,1)-[GAP]-x-N-{AGLS}-[STA]-x(2)-{A}-x-{G}-{GNKA}-[GS]-x(9)-G
|
| Sequences known to belong to this class detected by the pattern: |
ALL, except for ADK, gsk, kdgK, yeast ribokinase and YJR105w, B.subtilis yxdC and E.coli yihV |
| Other sequence(s) detected in Swiss-Prot: |
33. |
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| Matching PDB structures:
2AWD 2C49 2C4E 2F02 ... [ALL] |
| PFKB_KINASES_2, PS00584; pfkB family of carbohydrate kinases signature 2 (PATTERN) |
| Consensus pattern: |
[DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-[LIVMFYA]-[LIVMSTAP]
|
| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
5. |
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|
| Matching PDB structures:
1BX4 1DGM 1GQT 1LII ... [ALL] |
References:
| 1 |
Authors | Wu L.-F., Reizer A., Reizer J., Cai B., Tomich J.M., Saier M.H. Jr. |
| Title | Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. |
| Source | J. Bacteriol. 173:3117-3127(1991). |
| PubMed ID | 1850730 |
| 2 |
Authors | Orchard L.M.D., Kornberg H.L. |
| Title | Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus. |
| Source | Proc. R. Soc. Lond., B, Biol. Sci. 242:87-90(1990). |
| PubMed ID | 1981619 |
| 3 |
Authors | Blatch G.L., Scholle R.R., Woods D.R. |
| Title | Nucleotide sequence and analysis of the Vibrio alginolyticus sucrose uptake-encoding region. |
| Source | Gene 95:17-23(1990). |
| PubMed ID | 2174811 |
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