High potential iron-sulfur proteins (HiPIP) [1,2,E1] are a specific class of
high-redox potential 4Fe-4S ferredoxins that functions in anaerobic electron
transport and which occurs commonly in purple photosynthetic bacteria and in
other bacteria, such as Paracoccus denitrificans and Thiobacillus ferrooxidans
. HiPIPs seem to react by oxidation of [4Fe-4S]2+ to [4Fe-4S]3+.
The HiPIPs are small proteins which show significant variation in their
sequences, their sizes (from 63 to 85 amino acids), and in their oxidation-reduction potentials . As shown in the following schematic representation the
iron-sulfur cluster is bound by four conserved cysteine residues.
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