{PDOC00515}
{PS51373; HIPIP}
{BEGIN}
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* High potential iron-sulfur proteins family profile *
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High potential  iron-sulfur  proteins  (HiPIP)  [1,2]  are a specific class of
high-redox  potential  4Fe-4S ferredoxins that functions in anaerobic electron
transport  and  which occurs commonly in purple photosynthetic bacteria and in
other bacteria, such as Paracoccus denitrificans and Thiobacillus ferrooxidans
[3]. HiPIPs seem to react by oxidation of [4Fe-4S]2+ to [4Fe-4S]3+.

The  HiPIPs  are  small  proteins  which  show  significant variation in their
sequences,  their  sizes  (from 63 to 85 amino acids), and in their oxidation-
reduction  potentials . As shown in the following schematic representation the
iron-sulfur cluster is bound by four conserved cysteine residues.

                                     [        4Fe-4S cluster          ]
                                      |  |             |             |
  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCxxCxxxxxxxxxxxxxCxxxxxxxxxxxxxCxxxxxxx

'C': conserved cysteine involved in the binding of the iron-sulfur cluster.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2008 / Pattern removed, profile added and text revised.

[ 1] Breiter D.R., Meyer T.E., Rayment I., Holden H.M.
     "The molecular structure of the high potential iron-sulfur protein
     isolated from Ectothiorhodospira halophila determined at 2.5-A
     resolution."
     J. Biol. Chem. 266:18660-18667(1991).
     PubMed=1917989
[ 2] Kusano T., Takeshima T., Sugawara K., Inoue C., Shiratori T., Yano T.,
     Fukumori Y., Yamanaka T.
     "Molecular cloning of the gene encoding Thiobacillus ferrooxidans
     Fe(II) oxidase. High homology of the gene product with HiPIP."
     J. Biol. Chem. 267:11242-11247(1992).
     PubMed=1317860
[ 3] Van Driessche G., Vandenberghe I., Devreese B., Samyn B., Meyer T.E.,
     Leigh R., Cusanovich M.A., Bartsch R.G., Fischer U.,
     Van Beeumen J.J.
     "Amino acid sequences and distribution of high-potential iron-sulfur
     proteins that donate electrons to the photosynthetic reaction center
     in phototropic proteobacteria."
     J. Mol. Evol. 57:181-199(2003).
     PubMed=14562962; DOI=10.1007/s00239-003-2465-y

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