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| PROSITE documentation PDOC00547 |
Inositol monophosphatase family signatures
Description:
It has been shown [1] that several proteins share two sequence motifs. Two of
these proteins are enzymes of the inositol phosphate second messenger
signalling pathway:
- Vertebrate, plants and microbial myo-inositol monophosphatase
(EC 3.1.3.25).
- Vertebrate inositol polyphosphate 1-phosphatase (EC 3.1.3.57).
The function of the other proteins is not yet clear:
- Bacterial protein cysQ. CysQ could help to control the pool of PAPS
(3'-phosphoadenoside 5'-phosphosulfate), or be useful in sulfite synthesis.
- Neurospora crassa protein Qa-X. Probably involved in quinate metabolism.
- Emericella nidulans protein qutG. Probably involved in quinate metabolism.
- Yeast protein HAL2/MET22 [2] involved in salt tolerance as well as
methionine biosynthesis.
- Yeast hypothetical hypothetical protein YHR046c.
- Caenorhabditis elegans hypothetical protein F13G3.5.
It is suggested [1] that these proteins may act by enhancing the synthesis or
degradation of phosphorylated messenger molecules. From the X-ray structure of
human inositol monophosphatase [3], it seems that some of the conserved
residues are involved in binding a metal ion and/or the phosphate group of the
substrate.
Last update:
April 2006 / Pattern revised.
Technical section:
PROSITE methods (with tools and information) covered by this documentation:
| IMP_1, PS00629; Inositol monophosphatase family signature 1 (PATTERN) |
| Consensus pattern: |
[FWV]-x(0,1)-[LIVM]-D-P-[LIVM]-D-[SG]-[ST]-x(2)-[FYA]-x(0,1)-[HKRNSTY]
The first D and the T bind a metal ion |
| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
|
|
|
| Matching PDB structures:
1AWB 1DK4 1FLF 1G0H ... [ALL] |
| IMP_2, PS00630; Inositol monophosphatase family signature 2 (PATTERN) |
| Consensus pattern: |
[WYV]-D-x-[AC]-[GSA]-[GSAPV]-x-[LIVFACP]-[LIVM]-[LIVAC]-x(3)-[GH]-[GA]
|
| Sequences known to belong to this class detected by the pattern: |
ALL, except for cysQ from Mycobacterium leprae |
| Other sequence(s) detected in Swiss-Prot: |
1. |
|
|
|
| Matching PDB structures:
1AWB 1DK4 1FLF 1G0H ... [ALL] |
References:
| 1 |
Authors | Neuwald A.F., York J.D., Majerus P.W. |
| Title | Diverse proteins homologous to inositol monophosphatase. |
| Source | FEBS Lett. 294:16-18(1991). |
| PubMed ID | 1660408 |
| 2 |
Authors | Glaeser H.-U., Thomas D., Gaxiola R., Montrichard F., Surdin-Kerjan Y., Serrano R. |
| Source | EMBO J. 12:3105-3110(1993). |
| 3 |
Authors | Bone R., Springer J.P., Atack J.R. |
| Title | Structure of inositol monophosphatase, the putative target of lithium therapy. |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:10031-10035(1992). |
| PubMed ID | 1332026 |
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