{PDOC00552}
{PS00635; PILI_CHAPERONE}
{BEGIN}
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* Gram-negative pili assembly chaperone signature *
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Most Gram-negative bacteria possess a supramolecular structure - the pili - on
their surface, that mediates attachment to specific receptors. The assembly of
the pili  requires  the  help  of  specialized periplasmic chaperones [1,2,3].
These proteins  are  structurally  and  possibly  evolutionary  related to the
immunoglobulin family. Known members of this family are listed below:

 - Escherichia coli papD for P pili.
 - Escherichia coli afaB for AFA-III adhesin.
 - Escherichia coli aggD for AAF/I fimbriae.
 - Escherichia coli cssC for CS6 antigen.
 - Escherichia coli F17-D for F17 pili.
 - Escherichia coli faeE for K88 pili.
 - Escherichia coli fanE for K99 pili.
 - Escherichia coli fimC for type 1 fimbriae.
 - Escherichia coli focC for F1C fimbriae.
 - Escherichia coli nfaE for NFA-I adhesin.
 - Escherichia coli sfaE for S pili.
 - Escherichia coli clpE for CS31A capsule-like antigen.
 - Escherichia coli ecpD for a yet unknown pilin.
 - Escherichia coli CS3-1 for CS3 pili.
 - Bordetella  pertussis  fhaD  (or  fimB)  for  filamentous hemagglutinin and
   fimbria.
 - Haemophilus influenzae hifB for type b pili.
 - Klebsiella pneumoniae mrkB for type 3 pili.
 - Proteus mirabilis pmfD for PMF fimbriae.
 - Salmonella enteritidis sefB for sef14 fimbriae.
 - Salmonella typhimurium lpfB for long polar fimbriae.
 - Yersinia enterocolitica myfB for myf fimbriae.
 - Yersinia pestis caf1M for F1 capsule antigen.
 - Yersinia pestis psaB for pH6 antigen.
 - Escherichia coli hypothetical protein ybgP.
 - Escherichia coli hypothetical protein ycbF.
 - Escherichia coli hypothetical protein yehC.
 - Escherichia coli hypothetical protein yfcS.
 - Escherichia coli hypothetical protein yhcA.
 - Escherichia coli hypothetical protein yqiH.
 - Escherichia coli hypothetical protein yraI.

Structurally, these  proteins  consist of two globular domains with a topology
identical to  an  immunoglobulin  fold.  As a signature pattern, we selected a
highly conserved  region  located  in  the  C-terminal  section  of  the first
globular domain.

-Consensus pattern: [LIVMFY]-[APN]-x-[DNS]-[KREQ]-E-[STR]-[LIVMAR]-x-[FYWTE]-
                    x-[NCS]-[LIVM]-x(2)-[LIVM]-P-[PAS]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for ycbF and yhcA.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Hung D.L., Knight S.D., Woods R.M., Pinkner J.S., Hultgren S.J.
     "Molecular basis of two subfamilies of immunoglobulin-like
     chaperones."
     EMBO J. 15:3792-3805(1996).
     PubMed=8670884
[ 2] Jacob-Dubuisson F., Kuehn M.J., Hultgren S.J.
     Trends Microbiol. 1:50-55(1993).
[ 3] van Rosmalen M., Saier M.H. Jr.
     Res. Microbiol. 144:507-527(1993).

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