|PROSITE documentation PDOC00629|
A number of growth factors stimulate mitogenesis by interacting with a family of cell surface receptors which possess an intrinsic, ligand-sensitive, protein tyrosine kinase activity . These receptor tyrosine kinases (RTK) all share the same topology: an extracellular ligand-binding domain, a single transmembrane region and a cytoplasmic kinase domain. However they can be classified into at least five groups on the basis of sequence similarities. The extracellular domain of class V RTK's consist of a region of about 300 amino acids, amongst which 16 conserved cysteines probably involved in disulfide bonds; this region is followed by two copies of a fibronectin type III domain. The ligands for these receptors are proteins of about 200 to 300 residues collectively known as Ephrins (see <PDOC01003>). The receptors currently known to belong to class V are [2,3,E1]:
The EPHA subtype receptors bind to GPI-anchored ephrins while the EPHB subtype receptors bind to type-I membrane ephrins.
We developed two signature patterns for this class of RTK's, which each include some of the conserved cysteine residues.Last update:
April 2006 / Pattern revised.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Yarden Y., Ullrich A.|
|Title||Growth factor receptor tyrosine kinases.|
|Source||Annu. Rev. Biochem. 57:443-478(1988).|
|2||Authors||Sajjadi F.G., Pasquale E.B., Subramani S.|
|Title||Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor.|
|Source||New Biol. 3:769-778(1991).|
|3||Authors||Wicks I.P., Wilkinson D., Salvaris E., Boyd A.W.|
|Title||Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 89:1611-1615(1992).|