|PROSITE documentation PDOC00644
Erythropoietin / thrombopoeitin signature
Erythropoietin (EPO)  is the mammalian hormone involved in the regulation
of erythrocyte differentiation and the maintenance of a physiological level of
erythrocytes in the bloodstream. The mature form of EPO is a glycoprotein of
166 amino acid residues.
Thrombopoeitin (TPO)  is the mammalian hormone which functions as a
megakaryocytic lineage specific growth and differentiation factor. It acts as
a circulating regulator of platelet numbers. The mature form of TPO is a
glycoprotein of 330 amino acid residues.
EPO and TPO are evolutionary related. As a signature pattern, we selected a
conserved region located at the N-terminal extremity of mature EPO and TPO and
that includes two cysteines which have been shown, in human EPO, to be
implicated in disulfide bonds.
May 2004 / Text revised.
PROSITE method (with tools and information) covered by this documentation:
|EPO_TPO, PS00817; Erythropoietin / thrombopoeitin signature (PATTERN)
The 2 C's are involved in disulfide bonds
|Sequences known to belong to this class detected by the pattern:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
1BUY 1CN4 1EER [ALL]
||Koury M.J., Bondurant M.C.
||The molecular mechanism of erythropoietin action.
||Eur. J. Biochem. 210:649-663(1992).
||De Sauvage F.J., Hass P.E., Spencer S.D., Malloy B.E., Gurney A.L., Spencer S.A., Darbonne W.C., Henzel W.J., Wong S.C., Kuang W.J., Oles K.J., Hultgren B., Solberg L.A. Jr., Goeddel D.V., Eaton D.L.
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