{PDOC00644}
{PS00817; EPO_TPO}
{BEGIN}
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* Erythropoietin / thrombopoeitin signature *
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Erythropoietin (EPO)  [1]  is the mammalian hormone involved in the regulation
of erythrocyte differentiation and the maintenance of a physiological level of
erythrocytes in  the  bloodstream. The mature form of EPO is a glycoprotein of
166 amino acid residues.

Thrombopoeitin (TPO)  [2]  is  the  mammalian  hormone  which  functions  as a
megakaryocytic lineage specific growth and differentiation factor. It acts as
a circulating  regulator  of  platelet  numbers.  The  mature form of TPO is a
glycoprotein of 330 amino acid residues.

EPO and  TPO  are  evolutionary related. As a signature pattern, we selected a
conserved region located at the N-terminal extremity of mature EPO and TPO and
that includes  two  cysteines  which  have  been  shown,  in  human EPO, to be
implicated in disulfide bonds.

-Consensus pattern: P-x(4)-C-D-x-R-[LIVM](2)-x-[KR]-x(14)-C
                    [The 2 C's are involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Koury M.J., Bondurant M.C.
     "The molecular mechanism of erythropoietin action."
     Eur. J. Biochem. 210:649-663(1992).
     PubMed=1483451
[ 2] De Sauvage F.J., Hass P.E., Spencer S.D., Malloy B.E., Gurney A.L.,
     Spencer S.A., Darbonne W.C., Henzel W.J., Wong S.C., Kuang W.J.,
     Oles K.J., Hultgren B., Solberg L.A. Jr., Goeddel D.V., Eaton D.L.
     Nature 369:533-538(1994).

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