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PROSITE documentation PDOC00647

Cytochrome c and c1 heme lyases signatures

Description:

Cytochrome c heme lyase (CCHL) (EC 4.4.1.17) and cytochrome c1 heme lyase (CC1HL) [1] are mitochondrial enzymes that catalyze the covalent attachment of a heme group on two cysteine residues of cytochrome c and c1.

These two enzymes are functionally and evolutionary related. As signature patterns, we selected two conserved regions: the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the heme group.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE methods (with tools and information) covered by this documentation:

CYTO_HEME_LYASE_1, PS00821; Cytochrome c and c1 heme lyases signature 1  (PATTERN)
Consensus pattern: H-N-x(2)-N-E-x(2)-W-[NQKRS]-x(4)-W-E
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00821
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00821
• Scan Swiss-Prot/TrEMBL entries against PS00821
• view ligand binding statistics
CYTO_HEME_LYASE_2, PS00822; Cytochrome c and c1 heme lyases signature 2  (PATTERN)
Consensus pattern: P-F-D-R-H-D-W
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00822
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00822
• Scan Swiss-Prot/TrEMBL entries against PS00822
• view ligand binding statistics

Reference:

1 AuthorsZollner A., Roedel G., Haid A.
TitleMolecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase.
SourceEur. J. Biochem. 207:1093-1100(1992).
PubMed ID1499554

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