{PDOC00663}
{PS00848; COX5B_1}
{PS51359; COX5B_2}
{BEGIN}
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* Cytochrome c oxidase subunit Vb family signature and profile *
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Cytochrome c oxidase (EC 1.9.3.1) [1] is an oligomeric enzymatic complex which
is  a  component  of  the  respiratory  chain  complex  and is involved in the
transfer  of  electrons from cytochrome c to oxygen. In eukaryotes this enzyme
complex is located in the mitochondrial inner membrane; in aerobic prokaryotes
it  is  found  in the plasma membrane. In addition to the three large subunits
that form the catalytic center of the enzyme complex there are, in eukaryotes,
a  variable number of small polypeptidic subunits. One of these subunits which
is known as Vb in mammals, V in slime mold and IV in yeast, binds a zinc atom.
The  sequence  of  subunit  Vb  is  well  conserved and includes three to four
conserved cysteines that coordinate the zinc ion [2,3]. Two of these cysteines
are  clustered  in  the  C-terminal  section of the subunit; we have used this
region  as  a  signature  pattern. We also developed a profile that covers the
whole subunit Vb zinc binding region.

-Consensus pattern: [LIVM](2)-[FYW]-x(10)-C-x(2)-C-G-x(2)-[FY]-K-L
                    [The 2 C's may bind zinc]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: January 2008 / Text revised; profile added.

[ 1] Capaldi R.A., Malatesta F., Darley-Usmar V.M.
     "Structure of cytochrome c oxidase."
     Biochim. Biophys. Acta 726:135-148(1983).
     PubMed=6307356
[ 2] Rizzuto R., Sandona D., Brini M., Capaldi R.A., Bisson R.
     "The most conserved nuclear-encoded polypeptide of cytochrome c
     oxidase is the putative zinc-binding subunit: primary structure of
     subunit V from the slime mold Dictyostelium discoideum."
     Biochim. Biophys. Acta 1129:100-104(1991).
     PubMed=1661610
[ 3] Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H.,
     Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
     "The whole structure of the 13-subunit oxidized cytochrome c oxidase
     at 2.8 A."
     Science 272:1136-1144(1996).
     PubMed=8638158

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