PROSITE documentation PDOC00724

Ribosomal protein L1e signature

Description:

A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists [1,2,3,4] of:

  • Vertebrate L1 (L4).
  • Drosophila L1.
  • Plant L1.
  • Yeast L2 (Rp2).
  • Fission yeast L2.
  • Halobacterium marismortui HmaL4 (HL6).
  • Methanococcus jannaschii MJ0177.

These proteins have 246 (archaebacteria) to 427 (human) amino acids. As a signature pattern, we selected a conserved region in the N-terminal part of these proteins.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L1E, PS00939Ribosomal protein L1e signature  (PATTERN)
Consensus pattern: [NP]-x(3)-[KRM]-x(2)-A-[LIVTK]-x-[SA]-[AC]-[LIV]-x-[ALCM]-[STL]-[SGAKTI]-x(7)-[RK]-[GS]-H
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
Retrieve the sequence logo from the alignment
Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00939
Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00939
Scan Swiss-Prot/TrEMBL entries against PS00939
view ligand binding statistics
Matching PDB structures: 1FFK 1JJ2 1K5Y 1K73 ... [ALL]

References:

1 AuthorsRafti F., Gargiulo G., Manzi A., Malva C., Graziani F.
TitleSequence of the ribosomal protein cDNA of D. melanogaster homologous to the L1 ribosomal protein gene of X. laevis.
SourceNucleic Acids Res. 17:456-456(1989).
PubMed ID2492096
2 AuthorsPresutti C., Villa T., Bozzoni I.
TitleThe primary sequence of the Schizosaccharomyces pombe protein homologous to S.cerevisiae ribosomal protein L2.
SourceNucleic Acids Res. 21:3900-3900(1993).
PubMed ID8367312
3 AuthorsBagni C., Mariottini P., Annesi F., Amaldi F.
TitleHuman ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein.
SourceBiochim. Biophys. Acta 1216:475-478(1993).
PubMed ID8268230
4 AuthorsArndt E., Kroemer W., Hatakeyama T.
TitleOrganization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui.
SourceJ. Biol. Chem. 265:3034-3039(1990).
PubMed ID2406244

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