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	PROSITE documentation PDOC00727

The following prenyltransferases are evolutionary related [1,2]:

• Bacterial 4-hydroxybenzoate octaprenyltransferase (gene ubiA).
• Yeast mitochondrial para-hydroxybenzoate--polyprenyltransferase (gene COQ2).
• Protoheme IX farnesyltransferase (heme O synthase) from yeast and mammals (gene COX10) and from bacteria (genes cyoE or ctaB).

These proteins probably contain seven transmembrane segments. The best conserved region is located in a loop between the second and third of these segments and we used it as a signature pattern.

Last update:

April 2006 / Pattern revised.

PROSITE method (with tools and information) covered by this documentation:

UBIA, PS00943; UbiA prenyltransferase family signature  (PATTERN)

• Consensus pattern:
  N-x(3)-[DEH]-x(2)-[LIMFYT]-D-x(2)-[VM]-x-R-[ST]-x(2)-R-x(4)-[GYNKR]
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 798
  • detected by PS00943: 650 (true positives)
  • undetected by PS00943: 148 (148 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00943:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00943
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00943
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00943
• View ligand binding statistics of PS00943

1	Authors	Melzer M., Heide L.
	Title	Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli.
	Source	Biochim. Biophys. Acta 1212:93-102(1994).
	PubMed ID	8155731

2	Authors	Mogi T., Saiki K., Anraku Y.
	Title	Biosynthesis and functional role of haem O and haem A.
	Source	Mol. Microbiol. 14:391-398(1994).
	PubMed ID	7885224

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