{PDOC00727}
{PS00943; UBIA}
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* UbiA prenyltransferase family signature *
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The following prenyltransferases are evolutionary related [1,2]:

 - Bacterial 4-hydroxybenzoate octaprenyltransferase (gene ubiA).
 - Yeast   mitochondrial   para-hydroxybenzoate--polyprenyltransferase   (gene
   COQ2).
 - Protoheme IX farnesyltransferase (heme O synthase)  from  yeast and mammals
   (gene COX10) and from bacteria (genes cyoE or ctaB).

These proteins   probably  contain  seven  transmembrane  segments.  The  best
conserved region  is  located  in a loop between the second and third of these
segments and we used it as a signature pattern.

-Consensus pattern: N-x(3)-[DEH]-x(2)-[LIMFYT]-D-x(2)-[VM]-x-R-[ST]-x(2)-R-
                    x(4)-[GYNKR]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Melzer M., Heide L.
     "Characterization of polyprenyldiphosphate: 4-hydroxybenzoate
     polyprenyltransferase from Escherichia coli."
     Biochim. Biophys. Acta 1212:93-102(1994).
     PubMed=8155731
[ 2] Mogi T., Saiki K., Anraku Y.
     "Biosynthesis and functional role of haem O and haem A."
     Mol. Microbiol. 14:391-398(1994).
     PubMed=7885224

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