{PDOC00738} {PS00954; IGP_DEHYDRATASE_1} {PS00955; IGP_DEHYDRATASE_2} {BEGIN} ****************************************************** * Imidazoleglycerol-phosphate dehydratase signatures * ****************************************************** Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) is the enzyme that catalyzes the seventh step in the biosynthesis of histidine in bacteria, fungi and plants. In most organisms it is a monofunctional protein of about 22 to 29 Kd. In some bacteria such as Escherichia coli it is the C-terminal domain of a bifunctional protein that include a histidinol-phosphatase domain [1]. We developed two signature patterns that each include two consecutive histidine residues. -Consensus pattern: [LIVMY]-[DE]-x-H-H-x(2)-E-x(2)-[GCA]-[LIVM]-[STAVCL]- [LIVMF] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Consensus pattern: [GW]-x-[DNIE]-x-H(2)-x(2)-E-[STAGC]-x-[VMFYHS]-K -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: April 2006 / Pattern revised. [ 1] Carlomagno M.S., Chiariotti L., Alifano P., Nappo A.G., Bruni C.B. "Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons." J. Mol. Biol. 203:585-606(1988). PubMed=3062174 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}