{PDOC00740}
{PS00957; NAD_G3PDH}
{BEGIN}
**************************************************************
* NAD-dependent glycerol-3-phosphate dehydrogenase signature *
**************************************************************

NAD-dependent  glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) (GPD) catalyzes
the reversible   reduction   of   dihydroxyacetone  phosphate  to  glycerol-3-
phosphate. It is a eukaryotic cytosolic homodimeric protein of about 40 Kd. As
a signature  pattern  we  selected  a glycine-rich region that is probably [1]
involved in NAD-binding.

-Consensus pattern: [GSA]-[ATIVS]-[LIVMYCAFST]-K-[DN]-[LIVMA]-[LIVMFYT]-[GA]-
                    x-[GACKMSIFT]-x-G-[ALIVMF]-x(2)-[SGAQ]-[LIVMYERAKQFS]-
                    x(0,1)-[TLIVMFYWAQ]-[ETGAS]-x(0,1)-[NDVS]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Otto J., Argos P., Rossmann M.G.
     "Prediction of secondary structural elements in glycerol-3-phosphate
     dehydrogenase by comparison with other dehydrogenases."
     Eur. J. Biochem. 109:325-330(1980).
     PubMed=6773774

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}