Home ScanProsite ProRule Documents Downloads Links Funding
PROSITE documentation PDOC00752

Myristoyl-CoA:protein N-myristoyltransferase signatures

Description:

Myristoyl-CoA:protein N-myristoyltransferase (EC 2.3.1.97) (Nmt) [1] is the enzyme responsible for transferring a myristate group on the N-terminal glycine of a number of cellular eukaryotics and viral proteins.

Nmt is a monomeric protein of about 50 to 60 Kd whose sequence appears to be well conserved. We used two highly conserved regions as signature patterns. The first one is located in the central section, the second in the C-terminal part.

Last update:

April 2006 / Pattern revised.

Technical section:

PROSITE methods (with tools and information) covered by this documentation:

NMT_1, PS00975; Myristoyl-CoA:protein N-myristoyltransferase signature 1  (PATTERN)
Consensus pattern: [DEK]-[IV]-N-[FS]-L-C-x-H-K
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00975
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00975
• Scan Swiss-Prot/TrEMBL entries against PS00975
• view ligand binding statistics
Matching PDB structures: 1IIC 1IID 1IYK 1IYL ... [ALL]
NMT_2, PS00976; Myristoyl-CoA:protein N-myristoyltransferase signature 2  (PATTERN)
Consensus pattern: K-F-G-x-G-D-G
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: 1.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00976
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00976
• Scan Swiss-Prot/TrEMBL entries against PS00976
• view ligand binding statistics
Matching PDB structures: 1IIC 1IID 1IYK 1IYL ... [ALL]

Reference:

1 AuthorsRudnick D.A., McWherter C.A., Gokel G.W., Gordon J.I.
TitleMyristoylCoA:protein N-myristoyltransferase.
SourceAdv. Enzymol. Relat. Areas Mol. Biol. 67:375-430(1993).
PubMed ID8322618

Copyright:

PROSITE is copyright. It is produced by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: http://www.expasy.org/prosite/prosite_license.htm.

Miscellaneous:

View entry in original PROSITE document format
View entry in raw text format (no links)