{PDOC00773}
{PS01011; FOLYLPOLYGLU_SYNT_1}
{PS01012; FOLYLPOLYGLU_SYNT_2}
{BEGIN}
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* Folylpolyglutamate synthase signatures *
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Folylpolyglutamate synthase (EC 6.3.2.17)  (FPGS) [1] is  the enzyme of folate
metabolism that  catalyzes  ATP-dependent  addition  of  glutamate moieties to
tetrahydrofolate.

Its sequence  is  moderately  conserved  between  prokaryotes  (gene folC) and
eukaryotes. We developed two signature patterns based on the conserved regions
which are  rich  in  glycine residues and could play a role in the catalytical
activity and/or in substrate binding.

-Consensus pattern: [LIVMFY]-x-[LIVM]-[STAG]-G-T-[NK]-G-K-x-[STG]-x(4)-{A}-x-
                    {EAD}-[LIVM](2)-x(3,4)-[GSKQT]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 8.

-Consensus pattern: [LIVMFY](2)-[EK]-x-G-[LIVM]-[GA]-G-x(2)-D-x-[GST]-x-
                    [LIVM](2)
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Patterns and text revised.

[ 1] Shane B., Garrow T., Brenner A., Chen L., Choi Y.J., Hsu J.C.,
     Stover P.
     "Folylpoly-gamma-glutamate synthetase."
     Adv. Exp. Med. Biol. 338:629-634(1993).
     PubMed=8304196;

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