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| PROSITE documentation PDOC00783 |
Coproporphyrinogen III oxidase signature
Description:
Coproporphyrinogen III oxidase (EC 1.3.3.3) (coproporphyrinogenase) [1,2]
catalyzes the oxidative decarboxylation of coproporphyrinogen III into
protoporphyrinogen IX, a common step in the pathway for the biosynthesis of
porphyrins such as heme, chlorophyll or cobalamin.
Coproporphyrinogen III oxidase is an enzyme that requires iron for its
activity. A cysteine seems to be important for the catalytic mechanism [3].
Sequences from a variety of eukaryotic and prokaryotic sources show that
this enzyme has been evolutionarily conserved. As a signature pattern we
selected a highly conserved region in the central part of the sequence; this
region contains the only conserved cysteine and is rich in charged amino
acids.
Note:
Some bacteria possess an anaerobic form of coproporphyrinogen III
oxidase [4] which does not belong to this family.
Last update:
April 2006 / Pattern revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| COPROGEN_OXIDASE, PS01021; Coproporphyrinogen III oxidase signature (PATTERN) |
| Consensus pattern: |
K-x-[WQA]-[CA]-x(2)-[FYH](2)-x-[LIVM]-x-[HY]-R-x-E-x-R-G-[LIVMT]-G(2)-[LIVM]-F-[FY]-D
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
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| Matching PDB structures:
1TKL 1TLB 1TXN 1VJU ... [ALL] |
References:
| 1 |
Authors | Xu K., Elliott T. |
| Title | An oxygen-dependent coproporphyrinogen oxidase encoded by the hemF gene of Salmonella typhimurium. |
| Source | J. Bacteriol. 175:4990-4999(1993). |
| PubMed ID | 8349542 |
| 2 |
Authors | Kohno H., Furukawa T., Yoshinaga T., Tokunaga R., Taketani S. |
| Title | Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation. |
| Source | J. Biol. Chem. 268:21359-21363(1993). |
| PubMed ID | 8407975 |
| 3 |
Authors | Camadro J.M., Chambon H., Jolles J., Labbe P. |
| Title | Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. |
| Source | Eur. J. Biochem. 156:579-587(1986). |
| PubMed ID | 3516695 |
| 4 |
Authors | Xu K., Elliott T. |
| Title | Cloning, DNA sequence, and complementation analysis of the Salmonella typhimurium hemN gene encoding a putative oxygen-independent coproporphyrinogen III oxidase. |
| Source | J. Bacteriol. 176:3196-3203(1994). |
| PubMed ID | 8195073 |
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