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Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in many aspects of cellular function including the regulation of metabolic enzymes and proteins involved in signal transduction. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 Kd regulatory subunit (PR65), also called subunit A; this complex then associates with a third variable subunit (subunit B), which confers distinct properties to the holoenzyme [1]. One of the forms of the variable subunit is a 55 Kd protein (PR55) which is highly conserved in mammals - where three isoforms are known to exist -, Drosophila and yeast (gene CDC55). This subunit could perform a substrate recognition function or be responsible for targeting the enzyme complex to the appropriate subcellular compartment.

As signature patterns, we selected two perfectly conserved sequences of 15 residues; one located in the N-terminal region, the other in the center of the protein.

Hemmings B.A.

April 2006 / Pattern revised.

PROSITE methods (with tools and information) covered by this documentation:

PR55_1, PS01024; Protein phosphatase 2A regulatory subunit PR55 signature 1  (PATTERN)

Consensus pattern: E-F-D-Y-L-K-S-L-E-I-E-E-K-I-N Sequences known to belong to this class detected by the pattern: ALL Other sequence(s) detected in Swiss-Prot: NONE.

• Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01024 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01024 • Scan Swiss-Prot/TrEMBL entries against PS01024 • view ligand binding statistics

Matching PDB structures: 3DW8 [ALL]

PR55_2, PS01025; Protein phosphatase 2A regulatory subunit PR55 signature 2  (PATTERN)

Consensus pattern: [NH]-[AG]-H-[TAD]-Y-H-I-N-S-I-S-[LIVMN]-[NS]-S-D Sequences known to belong to this class detected by the pattern: ALL Other sequence(s) detected in Swiss-Prot: NONE.

• Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01025 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01025 • Scan Swiss-Prot/TrEMBL entries against PS01025 • view ligand binding statistics

Matching PDB structures: 3DW8 [ALL]

1	Authors	Mayer-Jaekel R., Hemmings B.A.
	Title	Protein phosphatase 2A--a 'menage a trois'.
	Source	Trends Cell Biol. 4:287-291(1994).
	PubMed ID	14731592

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