{PDOC00785}
{PS01024; PR55_1}
{PS01025; PR55_2}
{BEGIN}
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* Protein phosphatase 2A regulatory subunit PR55 signatures *
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Protein phosphatase 2A (PP2A) is a   serine/threonine  phosphatase involved in
many  aspects of  cellular  function  including   the  regulation of metabolic
enzymes and  proteins  involved  in  signal  transduction.  PP2A is a trimeric
enzyme that consists of a core composed of a catalytic subunit associated with
a 65 Kd  regulatory subunit (PR65),  also called subunit A;  this complex then
associates with a third  variable subunit (subunit B),  which confers distinct
properties to the holoenzyme [1].  One of the forms of the variable subunit is
a 55  Kd  protein  (PR55)  which  is highly conserved in mammals - where three
isoforms are known to exist -, Drosophila and yeast (gene CDC55). This subunit
could perform a substrate recognition function or be responsible for targeting
the enzyme complex to the appropriate subcellular compartment.

As signature  patterns, we selected  two  perfectly  conserved sequences of 15
residues; one  located  in  the  N-terminal region, the other in the center of
the protein.

-Consensus pattern: E-F-D-Y-L-K-S-L-E-I-E-E-K-I-N
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [NH]-[AG]-H-[TAD]-Y-H-I-N-S-I-S-[LIVMN]-[NS]-S-D
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Hemmings B.A.; hemmings@fmi.ch

-Last update: April 2006 / Pattern revised.

[ 1] Mayer-Jaekel R., Hemmings B.A.
     "Protein phosphatase 2A--a 'menage a trois'."
     Trends Cell Biol. 4:287-291(1994).
     PubMed=14731592;

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