{PDOC00787}
{PS01027; GLYCOSYL_HYDROL_F39}
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* Glycosyl hydrolases family 39 putative active site *
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It has  been  shown  [1,E1]  that  the  following  glycosyl  hydrolases can be
classified into a single family on the basis of sequence similarities:

 - Mammalian lysosomal alpha-L-iduronidase (EC 3.2.1.76).
 - Caldocellum  saccharolyticum  and  Thermoanaerobacter saccharolyticum beta-
   xylosidase (EC 3.2.1.37) (gene xynB).

The best  conserved  regions  in  these  enzymes is  located in the N-terminal
section. It   contains  a  glutamic  acid  residue  which,  on  the  basis  of
similarities with other  families of glycosyl hydrolases [2], probably acts as
the proton donor in the catalytic mechanism. We use this region as a signature
pattern.

-Consensus pattern: W-x-F-E-x-W-N-E-P-[DN]
                    [The second E may be the active site residue]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Henrissat B.; bernie@afmb.cnrs-mrs.fr

-Last update: May 2004 / Text revised.

[ 1] Henrissat B., Bairoch A.
     "New families in the classification of glycosyl hydrolases based on
     amino acid sequence similarities."
     Biochem. J. 293:781-788(1993).
     PubMed=8352747
[ 2] Henrissat B., Callebaut I., Fabrega S., Lehn P., Mornon J.-P., Davies G.
     "Conserved catalytic machinery and the prediction of a common fold for
     several families of glycosyl hydrolases."
     Proc. Natl. Acad. Sci. U.S.A. 92:7090-7094(1995).
     PubMed=7624375
[E1] https://www.uniprot.org/docs/glycosid

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