PROSITE documentation PDOC00789

Dehydroquinase class II signature

Description:

3-dehydroquinate dehydratase (EC 4.2.1.10), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homododecameric enzymes of about 17 Kd. They are found in some bacteria such as actinomycetales [1,2] and some fungi where they act in a catabolic pathway that allows the use of quinic acid as a carbon source. As a signature pattern, we selected a conserved region in the N-terminal section.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

DEHYDROQUINASE_II, PS01029Dehydroquinase class II signature  (PATTERN)
Consensus pattern: [LIVM]-[NQHS]-G-P-N-[LVI]-x(2)-[LT]-G-x-R-[QED]-x(3)-[FY]-G
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
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Matching PDB structures: 1D0I 1GQO 1GU0 1GU1 ... [ALL]

References:

1 AuthorsGarbe T., Servos S., Hawkins A., Dimitriadis G., Young D., Dougan G., Charles I.
TitleThe Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.
SourceMol. Gen. Genet. 228:385-392(1991).
PubMed ID1910148
2 AuthorsLalonde G., O'Hanley P.D., Stocker B.A.D., Denich K.T.
TitleCharacterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE.
SourceMol. Microbiol. 11:273-280(1994).
PubMed ID8170389

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