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| PROSITE documentation PDOC00789 |
Dehydroquinase class II signature
Description:
3-dehydroquinate dehydratase (EC 4.2.1.10), or dehydroquinase, catalyzes the
conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step
in the shikimate pathway for the biosynthesis of aromatic amino acids from
chorismate. Two classes of dehydroquinases exist, known as types I and II.
Class-II enzymes are homododecameric enzymes of about 17 Kd. They are found in
some bacteria such as actinomycetales [1,2] and some fungi where they act in a
catabolic pathway that allows the use of quinic acid as a carbon source. As a
signature pattern, we selected a conserved region in the N-terminal section.
Last update:
December 2004 / Pattern and text revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| DEHYDROQUINASE_II, PS01029; Dehydroquinase class II signature (PATTERN) |
| Consensus pattern: |
[LIVM]-[NQHS]-G-P-N-[LVI]-x(2)-[LT]-G-x-R-[QED]-x(3)-[FY]-G
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE |
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| Matching PDB structures:
1D0I 1GQO 1GU0 1GU1 ... [ALL] |
References:
| 1 |
Authors | Garbe T., Servos S., Hawkins A., Dimitriadis G., Young D., Dougan G., Charles I. |
| Title | The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. |
| Source | Mol. Gen. Genet. 228:385-392(1991). |
| PubMed ID | 1910148 |
| 2 |
Authors | Lalonde G., O'Hanley P.D., Stocker B.A.D., Denich K.T. |
| Title | Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. |
| Source | Mol. Microbiol. 11:273-280(1994). |
| PubMed ID | 8170389 |
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