{PDOC00789}
{PS01029; DEHYDROQUINASE_II}
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* Dehydroquinase class II signature *
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3-dehydroquinate dehydratase  (EC  4.2.1.10), or dehydroquinase, catalyzes the
conversion of  3-dehydroquinate  into 3-dehydroshikimate. It is the third step
in the  shikimate  pathway  for  the biosynthesis of aromatic amino acids from
chorismate. Two  classes  of dehydroquinases  exist,  known as types I and II.
Class-II enzymes are homododecameric enzymes of about 17 Kd. They are found in
some bacteria such as actinomycetales [1,2] and some fungi where they act in a
catabolic pathway  that allows the use of quinic acid as a carbon source. As a
signature pattern, we selected a conserved region in the N-terminal section.

-Consensus pattern: [LIVM]-[NQHS]-G-P-N-[LVI]-x(2)-[LT]-G-x-R-[QED]-x(3)-[FY]-
                    G
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Garbe T., Servos S., Hawkins A., Dimitriadis G., Young D., Dougan G.,
     Charles I.
     "The Mycobacterium tuberculosis shikimate pathway genes: evolutionary
     relationship between biosynthetic and catabolic 3-dehydroquinases."
     Mol. Gen. Genet. 228:385-392(1991).
     PubMed=1910148
[ 2] Lalonde G., O'Hanley P.D., Stocker B.A.D., Denich K.T.
     "Characterization of a 3-dehydroquinase gene from Actinobacillus
     pleuropneumoniae with homology to the eukaryotic genes qa-2 and
     QUTE."
     Mol. Microbiol. 11:273-280(1994).
     PubMed=8170389

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